Open AccessElastin molecular aging promotes MDA ‐ MB ‐231 breast cancer cell invasiveness
Author(s) -
Salesse Stéphanie,
Odoul Ludivine,
Chazée Lise,
Garbar Christian,
Duca Laurent,
Martiny Laurent,
Mahmoudi Rachid,
Debelle Laurent
Publication year - 2018
Publication title -
febs open bio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.718
H-Index - 31
ISSN - 2211-5463
DOI - 10.1002/2211-5463.12455
Subject(s) - elastin , breast cancer , extracellular matrix , cancer research , cancer , cell , cancer cell , chemistry , medicine , pathology , microbiology and biotechnology , biology , biochemistry
Elastin is a long‐lived extracellular matrix protein responsible for the structural integrity and function of tissues. Breast cancer elastosis is a complex phenomenon resulting in both the deposition of elastotic masses and the local production of elastin fragments. In invasive human breast cancers, an increase in elastosis is correlated with severity of the disease and age of the patient. Elastin‐derived peptides ( EDP s) are a hallmark of aging and are matrikines – matrix fragments having the ability to regulate cell physiology. They are known to promote processes linked to tumor progression, but their effects on breast cancer cells remain unexplored. Our data show that EDP s enhance the invasiveness of MDA ‐ MB ‐231 breast cancer cells through the engagement of matrix metalloproteases 14 and 2. We therefore suggest that elastosis and/or an aged stroma could promote breast cancer cell invasiveness.