Micro RNA  profiling during directed differentiation of cortical interneurons from human‐induced pluripotent stem cells | Zendy

Tu Jiajie | Zendy; Cao Dandan | Zendy; Li Lu | Zendy; Cheung HoiHung | Zendy; Chan WaiYee | Zendy

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Micro RNA profiling during directed differentiation of cortical interneurons from human‐induced pluripotent stem cells

Author(s) -

Tu Jiajie,

Cao Dandan,

Li Lu,

Cheung HoiHung,

Chan WaiYee

Publication year - 2018

Publication title -

febs open bio

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.718

H-Index - 31

ISSN - 2211-5463

DOI - 10.1002/2211-5463.12377

Subject(s) - induced pluripotent stem cell , microbiology and biotechnology , stem cell , biology , rna , directed differentiation , cellular differentiation , neuroscience , chemistry , embryonic stem cell , biochemistry , gene

Induced pluripotent stem cells ( iPSC s) are useful for modeling neuron development and related diseases. Cortical interneurons are essential players in neuropsychiatric diseases such as autism. mi RNA s are a class of pivotal regulators in neural differentiation. Using a previously established model of cortical interneuron differentiation from human embryonic stem cells, we profiled mi RNA s involved in differentiation from human iPSC s. A number of mi RNA s were modulated in the differentiation process. This study captured the temporal in vitro neurogenesis from iPSC s to mature cortical interneurons. The specific mi RNA s identified at each stage of differentiation are of potential use for drug discovery and prospective clinical applications.

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