IFITM1 suppresses expression of human endogenous retroviruses in human embryonic stem cells | Zendy

Fu Yudong | Zendy; Zhou Zhongcheng | Zendy; Wang Hua | Zendy; Gong Peng | Zendy; Guo Renpeng | Zendy; Wang Jinmiao | Zendy; Lu Xinyi | Zendy; Qi Feng | Zendy; Liu Lin | Zendy

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IFITM1 suppresses expression of human endogenous retroviruses in human embryonic stem cells

Author(s) -

Fu Yudong,

Zhou Zhongcheng,

Wang Hua,

Gong Peng,

Guo Renpeng,

Wang Jinmiao,

Lu Xinyi,

Qi Feng,

Liu Lin

Publication year - 2017

Publication title -

febs open bio

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.718

H-Index - 31

ISSN - 2211-5463

DOI - 10.1002/2211-5463.12246

Subject(s) - biology , embryonic stem cell , microbiology and biotechnology , telomerase , hek 293 cells , epigenetics , telomere , stem cell , endogeny , histone , transmembrane protein , endogenous retrovirus , cell culture , genetics , gene , biochemistry , genome , receptor

Interferon‐induced transmembrane protein 1 ( IFITM 1), a member of the IFITM protein family, is a component of a multimeric complex involved in the transduction of antiproliferation and cell adhesion signals. IFITM 1 is thought to play a role in antiproliferation and immune surveillance, and has been shown to restrict infection by numerous viruses. It is highly expressed in human embryonic stem cells ( hESC s) but its role in hESC s remains to be elucidated. In this study, knockout of IFITM 1 mediated by CRISPR /Cas9 in hESC s did not affect self‐renewal, pluripotency, telomerase activity or telomeres. However expression of human endogenous retroviruses ( HERV s) was higher than in wild‐type hESC s, and there was also a reduced level of trimethylation of histone H3 on lysine 9 at HERV loci. These data show that IFITM 1 suppresses HERV s in hESC s by regulating epigenetic modifications.

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