Open AccessA novel combination of four flavonoids derived from Astragali Radix relieves the symptoms of cyclophosphamide‐induced anemic rats
Author(s) -
Zhang Li,
Gong Amy G. W.,
Riaz Kashif,
Deng Jun Y.,
Ho Chih M.,
Lin Huang Q.,
Dong Tina T. X.,
Lee YiKuen,
Tsim Karl W. K.
Publication year - 2017
Publication title -
febs open bio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.718
H-Index - 31
ISSN - 2211-5463
DOI - 10.1002/2211-5463.12146
Subject(s) - calycosin , malondialdehyde , pharmacology , liquiritigenin , puerarin , erythropoietin , chemistry , formononetin , radix (gastropod) , ginseng , cyclophosphamide , hemoglobin , hematocrit , zinc protoporphyrin , traditional medicine , medicine , antioxidant , biochemistry , biology , chemotherapy , heme , daidzein , enzyme , genistein , botany , alternative medicine , pathology
By using a feedback system control scheme, the best combination of formononetin, ononin, calycosin, and calycosin‐7‐ O ‐β‐ d ‐glucoside derived from Astragali Radix was shown to activate a hypoxia response element, a regulator for erythropoietin (EPO) transcription, in kidney fibroblast. In cyclophosphamide‐induced anemic rats, the treatment of combined flavonoids, or EPO, improved the levels of red blood cells, white blood cells, hemoglobin, and hematocrit. In addition, the altered levels of antioxidant capacity, super oxidase dismutase, and malondialdehyde, triggered in anemic rats, were restored to control levels by the treatment of flavonoids. Here, we proposed a possible therapy by using the common flavonoids in treating anemia.