Open AccessRetracted: Micro RNA ‐520c enhances cell proliferation, migration, and invasion by suppressing IRF 2 in gastric cancer
Author(s) -
Li Yingru,
Wen Liqiang,
Wang Yang,
Zhou Taicheng,
Ma Ning,
Hou Zehui,
Jiang Zhipeng
Publication year - 2016
Publication title -
febs open bio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.718
H-Index - 31
ISSN - 2211-5463
DOI - 10.1002/2211-5463.12142
Subject(s) - cancer , gene silencing , cell growth , chemistry , microrna , cancer research , cancer cell , cell culture , microbiology and biotechnology , gene , biochemistry , biology , genetics
Dysregulation of micro RNA (mi RNA ) is actively involved in the development and progression of gastric cancer ( GC ). MiR‐520c was previously found to be overexpressed in GC specimens and cells. However, the clinical significance of miR‐520c and its biological function in GC remain largely unknown. Here, we found that miR‐520c expression in GC tissues was significantly increased compared to normal adjacent gastric tissues. Its increased level was prominently correlated with poor clinical parameters and prognosis of GC patients. Accordingly, the expression of miR‐520c was obviously elevated in GC cell lines as compared with gastric epithelial cells. Overexpression of miR‐520c in N‐87 cells significantly increased the proliferative ability, migration, and invasion of cancer cells, while miR‐520c silencing suppressed MKN ‐45 cell proliferation, migration, and invasion in vitro . Mechanically, miR‐520c inversely regulated interferon regulatory factor 2 ( IRF 2) abundance in GC cells. Herein, IRF 2 was found to be a downstream target of miR‐520c in GC . Furthermore, IRF 2 was down‐regulated in GC tissues compared to nontumor tissues. An inverse correlation between IRF 2 and miR‐520c expression was observed in GC cases. Taken together, miR‐520c may serve as a prognostic predictor and a therapeutic target for GC patients.