Open AccessIdentification of lung‐specific genes by meta‐analysis of multiple tissue RNA ‐seq data
Author(s) -
Xiong Min,
Heruth Daniel P.,
Zhang Li Qin,
Ye Shui Qing
Publication year - 2016
Publication title -
febs open bio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.718
H-Index - 31
ISSN - 2211-5463
DOI - 10.1002/2211-5463.12089
Subject(s) - pseudogene , lung , gene , pathogenesis , biology , rna , gene expression , genetics , medicine , immunology , genome
Lung‐specific genes play critically important roles in lung development, lung physiology, and pathogenesis of lung‐associated diseases. We performed a meta‐analysis of multiple tissue RNA ‐seq data to identify lung‐specific genes in order to better investigate their lung‐specific functions and pathological roles. We identified 83 lung‐specific genes consisting of 62 protein‐coding genes, five pseudogenes and 16 noncoding RNA genes. About 49.4% of lung‐specific genes were implicated in the pathogenesis of lung diseases and 21.7% were involved with lung development. The identification of genes with enriched expression in the lung will facilitate the elucidation of lung‐specific functions and their roles in disease pathogenesis.