Open AccessExpression of nephronectin is enhanced by 1α,25‐dihydroxyvitamin D 3
Author(s) -
Hiranuma Katsuhiro,
Yamada Atsushi,
Kurosawa Tamaki,
Aizawa Ryo,
Suzuki Dai,
Saito Yoshiro,
Nagahama Ryo,
Ikehata Mikiko,
Tsukasaki Masayuki,
Morimura Naoko,
Chikazu Daichi,
Maki Koutaro,
Shirota Tatsuo,
Takami Masamichi,
Yamamoto Matsuo,
Iijima Takehiko,
Kamijo Ryutaro
Publication year - 2016
Publication title -
febs open bio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.718
H-Index - 31
ISSN - 2211-5463
DOI - 10.1002/2211-5463.12085
Subject(s) - calcitriol receptor , extracellular matrix , extracellular , vitamin d and neurology , messenger rna , gene expression , microbiology and biotechnology , receptor , calcitriol , vitamin , endocrinology , gene , chemistry , medicine , biology , biochemistry
The extracellular matrix protein nephronectin (Npnt), also called POEM , is considered to play critical roles as an adhesion molecule in development and functions of various tissues, such as the kidneys, liver, and bone. In the present study, we examined the molecular mechanism of Npnt gene expression and found that vitamin D 3 (1α,25‐dihydroxyvitamin D 3 , VD 3 ) strongly enhanced Npnt mRNA expression in MC 3T3‐E1 cells from a mouse osteoblastic cell line. The VD 3 ‐induced increase in Npnt expression is both time‐ and dose‐dependent and is mediated by the vitamin D receptor ( VDR ).