Open AccessPrognostic significance of lymphocyte‐to‐monocyte ratio in diffuse large B‐cell lymphoma: a systematic review and meta‐analysis
Author(s) -
Xia WenKai,
Lin QingFeng,
Shen Dong,
Liu ZhiLi,
Su Jun,
Mao WeiDong
Publication year - 2016
Publication title -
febs open bio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.718
H-Index - 31
ISSN - 2211-5463
DOI - 10.1002/2211-5463.12066
Subject(s) - diffuse large b cell lymphoma , medicine , meta analysis , lymphoma , oncology , subgroup analysis , biomarker , lymphocyte , overall survival , monocyte , biology , biochemistry
Published evidence on the prognostic significance of lymphocyte‐to‐monocyte ratio (LMR) in diffuse large B‐cell lymphoma (DLBCL) is controversial. We performed an updated meta‐analysis from 12 reports with 5021 patients to more accurately evaluate the prognostic value of LMR in DLBCL. Herein, we confirmed that patients with low LMR had shorter overall survival and progression‐free survival than those with high LMR in DLBCL. Subgroup analyses indicated that patient source, cut‐off values of LMR, treatment methods, and sample size showed similar prognostic performance in DLBCL patients. No significant heterogeneity was observed for progression‐free survival (PFS, P het = 0.192) among the enrolled studies. The meta‐analysis suggests that the LMR may be a potential biomarker in the prediction of clinical outcomes for DLBCL patients.