Open AccessHigh expression of Fatty Acid‐Binding Protein 5 promotes cell growth and metastatic potential of colorectal cancer cells
Author(s) -
Kawaguchi Koichiro,
Senga Shogo,
Kubota Chiaki,
Kawamura Yuki,
Ke Youqiang,
Fujii Hiroshi
Publication year - 2016
Publication title -
febs open bio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.718
H-Index - 31
ISSN - 2211-5463
DOI - 10.1002/2211-5463.12031
Subject(s) - colorectal cancer , fatty acid binding protein , cancer research , cell , cell growth , biomarker , cancer , downregulation and upregulation , fatty acid , chemistry , biochemistry , biology , medicine , gene
Fatty acid‐binding proteins ( FABP s) are responsible for binding and storing hydrophobic ligands such as long‐chain fatty acids, and for transporting these ligands to the appropriate compartments within the cell. The present study demonstrates that the FABP 5 gene is upregulated in colorectal cancer cells compared to normal colon cells in a manner that correlates with disease stage and that FABP 5 significantly promotes colorectal cancer cell growth and metastatic potential. Thus, FABP 5 might be a promising prognostic or therapeutic biomarker candidate in human colorectal cancer.