Open AccessThe role of aging in cancer
Author(s) -
Havas Aaron,
Yin Shanshan,
Adams P. D.
Publication year - 2022
Publication title -
molecular oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.332
H-Index - 88
eISSN - 1878-0261
pISSN - 1574-7891
DOI - 10.1002/1878-0261.13302
Subject(s) - proteostasis , telomere , epigenetics , biology , cellular senescence , senescence , telomerase , somatic cell , dna damage , cancer , genetics , dna methylation , biological age , bioinformatics , dna , evolutionary biology , gene , gene expression , phenotype
Many cancers show an increase in incidence with age, and age is the biggest single risk factor for many cancers. However, the molecular basis of this relationship is poorly understood. Through a collection of review articles, our thematic issue discusses the link between aging and cancer in aspects including somatic mutations, proteostasis, mitochondria, metabolism, senescence, epigenetic regulation, immune regulation, DNA damage, and telomere function.