Open AccessBispecific antibodies come to the aid of cancer immunotherapy
Author(s) -
Amelio Ivano,
Melino Gerry,
Levine Arnold J.
Publication year - 2021
Publication title -
molecular oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.332
H-Index - 88
eISSN - 1878-0261
pISSN - 1574-7891
DOI - 10.1002/1878-0261.12977
Subject(s) - bispecific antibody , cancer immunotherapy , immunotherapy , antibody , immune system , antigen , cancer , immunology , mutant , cancer research , cd8 , medicine , biology , monoclonal antibody , genetics , gene
Three collaborative studies published by the groups of Vogelstein, Gabelli, and Zhou report the development of specially designed bispecific antibodies that may help in overcoming the limitations of current immunotherapies. The bispecific antibodies have been designed to couple cells harboring HLA‐presented tumor‐specific antigens from Tp53 mutant or Ras mutant with CD4 and CD8 T cells, thus facilitating immune‐mediated clearance of the cancer cells.