Open AccessMolecular profiling of long‐term responders to immune checkpoint inhibitors in advanced non‐small cell lung cancer
Author(s) -
Frigola Joan,
Navarro Alejandro,
Carbonell Caterina,
Callejo Ana,
Iranzo Patricia,
Cedrés Susana,
MartinezMarti Alex,
Pardo Nuria,
SaoudiGonzalez Nadia,
Martinez Debora,
Jimenez Jose,
Sansano Irene,
Mancuso Francesco M.,
Nuciforo Paolo,
Montuenga Luis M.,
SánchezCespedes Montse,
Prat Aleix,
Vivancos Ana,
Felip Enriqueta,
Amat Ramon
Publication year - 2021
Publication title -
molecular oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.332
H-Index - 88
eISSN - 1878-0261
pISSN - 1574-7891
DOI - 10.1002/1878-0261.12891
Subject(s) - immunotherapy , oncology , medicine , lung cancer , immune system , pd l1 , somatic cell , cd8 , cohort , gene expression profiling , immunology , cancer research , biology , gene , gene expression , genetics
We molecularly characterized tumors from non‐small cell lung cancer patients, focusing on long‐term responders to immune checkpoint inhibitors and showed that these patients present high tumor mutation burden and low somatic copy number alteration burden. PD‐L1 expression was also enriched in these patients. Finally, we validated our findings by reanalyzing two public datasets.