Open AccessGenomic and prognostic heterogeneity among RAS/BRAF V600E / TP53 co‐mutated resectable colorectal liver metastases
Author(s) -
Berg Kaja C. G.,
Brunsell Tuva H.,
Sveen Anita,
Alagaratnam Sharmini,
Bjørnslett Merete,
Hektoen Merete,
Brudvik Kristoffer W.,
Røsok Bård I.,
Bjørnbeth Bjørn Atle,
Nesbakken Arild,
Lothe Ragnhild A.
Publication year - 2021
Publication title -
molecular oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.332
H-Index - 88
eISSN - 1878-0261
pISSN - 1574-7891
DOI - 10.1002/1878-0261.12885
Subject(s) - neuroblastoma ras viral oncogene homolog , kras , colorectal cancer , hazard ratio , medicine , v600e , oncology , mutation , genetic heterogeneity , confidence interval , cancer , cancer research , biology , gene , genetics , phenotype
Colorectal cancer commonly metastasizes into multiple liver foci, but intermetastatic heterogeneity remains poorly described. Here, we demonstrate that mutations of RAS/BRAF/TP53 are homogeneous within patients, while DNA copy number aberrations can vary greatly. RAS/BRAF/TP53 co‐mutations conferred a dismal prognosis, and co‐mutations combined with a high burden and heterogeneity of copy number aberrations identified patients with the poorest outcome.