Open AccessRefining immunotherapeutic approaches to high‐risk neuroblastoma based on tumor genomic profiles
Author(s) -
Grossmann Liron D.,
Maris John M.
Publication year - 2021
Publication title -
molecular oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.332
H-Index - 88
eISSN - 1878-0261
pISSN - 1574-7891
DOI - 10.1002/1878-0261.12880
Subject(s) - neuroblastoma , immunotherapy , biomarker , computational biology , chromosome , biology , cancer research , gene , cancer , genetics , cell culture
In this issue, Coronado et al . attempt to improve our understanding of the factors affecting the response to immunotherapy in a large subset of high‐risk neuroblastoma with hemizygous deletion of chromosome 11q. By using several computational approaches, the authors study potential transcriptional and post‐transcriptional pathways that may affect the response to immunotherapy and further be leveraged therapeutically in a biomarker‐directed fashion.