Open AccessThe melanoma brain metastatic microenvironment: aldolase C partakes in shaping the malignant phenotype of melanoma cells – a case of inter‐tumor heterogeneity
Author(s) -
Izraely Sivan,
BenMenachem Shlomit,
SagiAssif Orit,
Meshel Tsipi,
Malka Sapir,
Telerman Alona,
Bustos Matias A.,
Ramos Romela Irene,
PasmanikChor Metsada,
Hoon Dave S. B.,
Witz Isaac P.
Publication year - 2021
Publication title -
molecular oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.332
H-Index - 88
eISSN - 1878-0261
pISSN - 1574-7891
DOI - 10.1002/1878-0261.12872
Subject(s) - melanoma , cancer research , biology , microglia , tumor microenvironment , phenotype , metastasis , malignancy , cancer , immunology , inflammation , gene , genetics , tumor cells
The melanoma‐microglia cross‐talk upregulates the expression of aldolase C (ALDOC) in melanoma cells from several patients. The response of melanoma cells from 2 different patients to ALDOC upregulation was diametrically divergent. Whereas several metastasis‐associated functions including brain metastasis formation were augmented in one melanoma cell line (Mel 1), these functions were attenuated in the other melanoma cell line (Mel 2).