Open AccessInteraction of transcription factor AP‐2 gamma with proto‐oncogene PELP1 promotes tumorigenesis by enhancing RET signaling
Author(s) -
Liu Junhao,
Liu Zexuan,
Li Mengxing,
Tang Weiwei,
Pratap Uday P.,
Luo Yiliao,
Altwegg Kristin A.,
Li Xiaonan,
Zou Yi,
Zhu Hong,
Sareddy Gangadhara R.,
Viswanadhapalli Suryavathi,
Vadlamudi Ratna K.
Publication year - 2021
Publication title -
molecular oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.332
H-Index - 88
eISSN - 1878-0261
pISSN - 1574-7891
DOI - 10.1002/1878-0261.12871
Subject(s) - gene knockdown , coactivator , transcription factor , biology , cancer research , nuclear receptor , medicine , endocrinology , gene , biochemistry
Transcription factor AP‐2 gamma (TFAP2C) is a known regulator of the estrogen receptor, and high expression of TFAP2C is associated with therapy resistance. This study identified PELP1 as a TFAP2C interacting protein. PELP1 is essential for optimal TFAP2C transcriptional functions. TFAP2C interactions with PELP1 confer a growth advantage to breast cancer (BC) cells by activating an oncogenic RET signaling thus contributing to BC progression and therapy resistance.