Open AccessMultifaceted activities of transcription factor EB in cancer onset and progression
Author(s) -
Astanina Elena,
Bussolino Federico,
Doronzo Gabriella
Publication year - 2021
Publication title -
molecular oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.332
H-Index - 88
eISSN - 1878-0261
pISSN - 1574-7891
DOI - 10.1002/1878-0261.12867
Subject(s) - tfeb , basic helix loop helix leucine zipper transcription factors , biology , transcription factor , microphthalmia associated transcription factor , epigenetics , cancer research , microbiology and biotechnology , genetics , gene , dna binding protein
Transcription factor EB (TFEB) in stressed cells activates autophagic flux and lysosome biogenesis. Besides this canonical pathway, emerging findings indicate that TFEB regulates cell cycle, metabolism and inflammation. This review summarizes the role of TFEB in cancer onset and progression and advances multiple roles as an oncogene and regulator of the crosstalk circuits between cancer cells and tumor microenvironment (TME).