Open AccessLong non‐coding RNA RACGAP1P promotes breast cancer invasion and metastasis via miR‐345‐5p/RACGAP1‐mediated mitochondrial fission
Author(s) -
Zhou Danmei,
Ren Kehan,
Wang Meili,
Wang Jigang,
Li Ermin,
Hou Chenjian,
Su Ying,
Jin Yiting,
Zou Qiang,
Zhou Ping,
Liu Xiuping
Publication year - 2021
Publication title -
molecular oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.332
H-Index - 88
eISSN - 1878-0261
pISSN - 1574-7891
DOI - 10.1002/1878-0261.12866
Subject(s) - breast cancer , mitochondrial fission , biology , cancer research , metastasis , microrna , cancer , mitochondrion , microbiology and biotechnology , gene , genetics
In this study, we illustrate the potential mechanism of RACGAP1P implicated in breast cancer invasion and metastasis. In breast cancer cells, RACGAP1P could competitively bind to miR‐345‐5p, which targets RACGAP1, and therefore up‐regulate RACGAP1. RACGAP1P overexpression promoted mitochondrial fission‐mediated cell invasion via the RACGAP1P/miR‐345‐5p/RACGAP1/Drp1 network.