Open AccessA novel circular RNA, hsa_circ_0030998 suppresses lung cancer tumorigenesis and Taxol resistance by sponging miR‐558
Author(s) -
Li Xiaoping,
Feng Yiling,
Yang Bo,
Xiao Ting,
Ren Haixia,
Yu Xi,
Li Lei,
Li Mingjiang,
Zhang Weidong
Publication year - 2021
Publication title -
molecular oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.332
H-Index - 88
eISSN - 1878-0261
pISSN - 1574-7891
DOI - 10.1002/1878-0261.12852
Subject(s) - circular rna , lung cancer , microrna , carcinogenesis , cancer research , downregulation and upregulation , suppressor , biology , cancer , rna , tumor progression , medicine , gene , biochemistry , genetics
In the normal lung tissues, hsa_circ_0030998 get a balance level. Our study verified that the downregulated hsa_circ_0030998 can inhibit proliferation, migration, invasion and Taxol resistance by sponging miR‐558 in lung cancer. Therefore, the hsa_circ_0030998/miR‐558 axis might be a possible diagnostic and therapeutic target in lung cancer patients.