Open AccessTargeting immunogenic cell death in cancer
Author(s) -
Ahmed Asma,
Tait Stephen W.G.
Publication year - 2020
Publication title -
molecular oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.332
H-Index - 88
eISSN - 1878-0261
pISSN - 1574-7891
DOI - 10.1002/1878-0261.12851
Subject(s) - immunogenic cell death , oncolytic virus , immune system , programmed cell death , cancer research , cancer cell , cancer , cancer immunotherapy , immunotherapy , biology , immunology , medicine , apoptosis , biochemistry , genetics
Immunogenic cell death (ICD) is a form of cell death that can engage immunity. Therapeutic engagement of ICD in cancer may lead to more effective responses by eliciting antitumor immunity. Here, we discuss various modalities of ICD, highlighting our current understanding of the molecular basis of ICD. Finally, we outline the potential and challenge of harnessing ICD in cancer immunotherapy.