Open AccessMolecular genomic features associated with in vitro response of the NCI‐60 cancer cell line panel to natural products
Author(s) -
Krushkal Julia,
Negi Simarjeet,
Yee Laura M.,
Evans Jason R.,
Grkovic Tanja,
Palmisano Alida,
Fang Jianwen,
Sankaran Hari,
McShane Lisa M.,
Zhao Yingdong,
O'Keefe Barry R.
Publication year - 2021
Publication title -
molecular oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.332
H-Index - 88
eISSN - 1878-0261
pISSN - 1574-7891
DOI - 10.1002/1878-0261.12849
Subject(s) - biology , natural product , gene , cancer , computational biology , genetics , cancer research , biochemistry
Natural products provide new opportunities for anticancer chemotherapeutics. We examined the associations of molecular features in the NCI‐60 cancer cell lines with response to 1302 plant, marine, and microbial compounds. Expression or mutations in multiple genes were associated with treatment responses, suggesting potential mechanisms of action of natural compounds. This information will assist in future design of new chemotherapy agents.