Open AccessLoss of STAT5A promotes glucose metabolism and tumor growth through miRNA‐23a‐AKT signaling in hepatocellular carcinoma
Author(s) -
Jiang Yabo,
Tao Yongzhen,
Zhang Xiuping,
Wei Xubiao,
Li Min,
He Xuxiao,
Zhou Bin,
Guo Weixing,
Yin Huiyong,
Cheng Shuqun
Publication year - 2021
Publication title -
molecular oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.332
H-Index - 88
eISSN - 1878-0261
pISSN - 1574-7891
DOI - 10.1002/1878-0261.12846
Subject(s) - hepatocellular carcinoma , protein kinase b , cancer research , microrna , metabolism , signal transduction , carbohydrate metabolism , biology , medicine , chemistry , endocrinology , microbiology and biotechnology , biochemistry , gene
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer deaths worldwide. Metabolic reprogramming has been recognized as a core feature in HCC. In line with this idea, we verified that increased miR‐23a inhibited STAT5A expression and promoted glucose metabolism through activated AKT phosphorylation in HCC. This new signaling pathway may offer new treatment target for HCC patients.