Open AccessBAP1 suppresses prostate cancer progression by deubiquitinating and stabilizing PTEN
Author(s) -
Deng Rong,
Guo Yanmin,
Li Lian,
He Jianfeng,
Qiang Zhe,
Zhang Hailong,
Chen Ran,
Wang Yanli,
Zhao Xian,
Yu Jianxiu
Publication year - 2021
Publication title -
molecular oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.332
H-Index - 88
eISSN - 1878-0261
pISSN - 1574-7891
DOI - 10.1002/1878-0261.12844
Subject(s) - pten , deubiquitinating enzyme , cancer research , bap1 , protein kinase b , pi3k/akt/mtor pathway , prostate cancer , cancer , signal transduction , ubiquitin , gene knockdown , biology , metastasis , microbiology and biotechnology , apoptosis , gene , melanoma , biochemistry , genetics
PTEN protein levels are regulated through ubiquitination. Here, we identify BAP1 as a deubiquitinase that physically binds to and deubiquitinates PTEN, thereby inhibiting PTEN degradation. Stabilized PTEN suppresses prostate cancer progression by inhibiting Akt phosphorylation.