BAP1 suppresses prostate cancer progression by deubiquitinating and stabilizing PTEN | Zendy

Deng Rong | Zendy; Guo Yanmin | Zendy; Li Lian | Zendy; He Jianfeng | Zendy; Qiang Zhe | Zendy; Zhang Hailong | Zendy; Chen Ran | Zendy; Wang Yanli | Zendy; Zhao Xian | Zendy; Yu Jianxiu | Zendy

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BAP1 suppresses prostate cancer progression by deubiquitinating and stabilizing PTEN

Author(s) -

Deng Rong,

Guo Yanmin,

Li Lian,

He Jianfeng,

Qiang Zhe,

Zhang Hailong,

Chen Ran,

Wang Yanli,

Zhao Xian,

Yu Jianxiu

Publication year - 2021

Publication title -

molecular oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.332

H-Index - 88

eISSN - 1878-0261

pISSN - 1574-7891

DOI - 10.1002/1878-0261.12844

Subject(s) - pten , deubiquitinating enzyme , cancer research , bap1 , protein kinase b , pi3k/akt/mtor pathway , prostate cancer , cancer , signal transduction , ubiquitin , gene knockdown , biology , metastasis , microbiology and biotechnology , apoptosis , gene , melanoma , biochemistry , genetics

PTEN protein levels are regulated through ubiquitination. Here, we identify BAP1 as a deubiquitinase that physically binds to and deubiquitinates PTEN, thereby inhibiting PTEN degradation. Stabilized PTEN suppresses prostate cancer progression by inhibiting Akt phosphorylation.

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