Open AccessMulti‐kinase framework promotes proliferation and invasion of lung adenocarcinoma through activation of dynamin‐related protein 1
Author(s) -
Chung KueiPin,
Huang YenLin,
Chen YiJung,
Juan YiHsiu,
Hsu ChiaLang,
Nakahira Kiichi,
Huang YenTsung,
Lin MongWei,
Wu ShangGin,
Shih JinYuan,
Chang YihLeong,
Yu ChongJen
Publication year - 2021
Publication title -
molecular oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.332
H-Index - 88
eISSN - 1878-0261
pISSN - 1574-7891
DOI - 10.1002/1878-0261.12843
Subject(s) - dnm1l , cancer research , adenocarcinoma , mitochondrial fission , biology , protein kinase b , mitochondrion , microbiology and biotechnology , phosphorylation , cancer , genetics
Here, we demonstrated that the multikinase framework including ERK/AKT and CDK2 promotes the proliferation and invasion of lung adenocarcinoma cell lines through activating DRP1. Our results further uncovered the prognostic significance of DRP1 in early‐stage lung adenocarcinoma, showing that the expression and activation of DRP1 are both significantly associated with an increased risk of postoperative recurrence.