Open AccessDiscovery of novel DNA methylation biomarkers for non‐invasive sporadic breast cancer detection in the Latino population
Author(s) -
Cappetta Mónica,
Fernandez Lucía,
Brigi Lucía,
Artagaveytia Nora,
Bonilla Carolina,
López Miguel,
Esteller Manel,
Bertoni Bernardo,
Berdasco María
Publication year - 2021
Publication title -
molecular oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.332
H-Index - 88
eISSN - 1878-0261
pISSN - 1574-7891
DOI - 10.1002/1878-0261.12842
Subject(s) - breast cancer , epigenetics , dna methylation , biomarker , methylation , cpg site , population , biomarker discovery , oncology , cancer , biology , cancer research , medicine , bioinformatics , genetics , gene , gene expression , proteomics , environmental health
Epigenetic alterations are already being incorporated as robust biomarkers for prediction of cancer risk. Despite this success, validation in specific populations with different genetic backgrounds and variable lifestyle and environmental exposures is necessary. In this paper, we investigate the potential of blood DNA methylation as a non‐invasive test for detection of sporadic breast cancer biomarker in the Latin American population.