Periostin + cancer‐associated fibroblasts promote lymph node metastasis by impairing the lymphatic endothelial barriers in cervical squamous cell carcinoma | Zendy

Wei WenFei | Zendy; Chen XiaoJing | Zendy; Liang LuoJiao | Zendy; Yu Lan | Zendy; Wu XiangGuang | Zendy; Zhou ChenFei | Zendy; Wang ZiCi | Zendy; Fan LiangSheng | Zendy; Hu Zheng | Zendy; Liang Li | Zendy; Wang Wei | Zendy

Open Access

Periostin + cancer‐associated fibroblasts promote lymph node metastasis by impairing the lymphatic endothelial barriers in cervical squamous cell carcinoma

Author(s) -

Wei WenFei,

Chen XiaoJing,

Liang LuoJiao,

Yu Lan,

Wu XiangGuang,

Zhou ChenFei,

Wang ZiCi,

Fan LiangSheng,

Hu Zheng,

Liang Li,

Wang Wei

Publication year - 2021

Publication title -

molecular oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.332

H-Index - 88

eISSN - 1878-0261

pISSN - 1574-7891

DOI - 10.1002/1878-0261.12837

Subject(s) - periostin , stromal cell , cancer research , cancer associated fibroblasts , medicine , lymphatic system , metastasis , lymphatic endothelium , lymphangiogenesis , tumor microenvironment , cancer cell , lymphovascular invasion , fibroblast activation protein, alpha , cancer , focal adhesion , pathology , biology , signal transduction , microbiology and biotechnology , extracellular matrix

In this study, we identified a specific periostin + CAF subset that promoted lymph node metastasis (LNM) in cervical squamous cell carcinoma (CSCC). Periostin + CAFs impaired lymphatic endothelial barriers by activating the integrin‐FAK/Src‐VE‐cadherin signaling pathway in lymphatic endothelial cells and consequently enhanced metastatic dissemination. Blocking periostin or its downstream effectors (using inhibitors) FAK (PF‐562271)/Src (BMS‐354825 monohydrate) may inhibit periostin + CAFs‐induced LNM.

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