Open AccessPeriostin + cancer‐associated fibroblasts promote lymph node metastasis by impairing the lymphatic endothelial barriers in cervical squamous cell carcinoma
Author(s) -
Wei WenFei,
Chen XiaoJing,
Liang LuoJiao,
Yu Lan,
Wu XiangGuang,
Zhou ChenFei,
Wang ZiCi,
Fan LiangSheng,
Hu Zheng,
Liang Li,
Wang Wei
Publication year - 2021
Publication title -
molecular oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.332
H-Index - 88
eISSN - 1878-0261
pISSN - 1574-7891
DOI - 10.1002/1878-0261.12837
Subject(s) - periostin , stromal cell , cancer research , cancer associated fibroblasts , lymphatic system , medicine , lymphatic endothelium , metastasis , tumor microenvironment , lymphangiogenesis , cancer cell , lymphovascular invasion , focal adhesion , pathology , cancer , biology , signal transduction , microbiology and biotechnology , extracellular matrix , tumor cells
In this study, we identified a specific periostin + CAF subset that promoted lymph node metastasis (LNM) in cervical squamous cell carcinoma (CSCC). Periostin + CAFs impaired lymphatic endothelial barriers by activating the integrin‐FAK/Src‐VE‐cadherin signaling pathway in lymphatic endothelial cells and consequently enhanced metastatic dissemination. Blocking periostin or its downstream effectors (using inhibitors) FAK (PF‐562271)/Src (BMS‐354825 monohydrate) may inhibit periostin + CAFs‐induced LNM.