Open Access5‐Hydroxymethylcytosine signature in circulating cell‐free DNA as a potential diagnostic factor for early‐stage colorectal cancer and precancerous adenoma
Author(s) -
Xiao ZeWen,
Wu Wendy,
Wu Chunlong,
Li Man,
Sun Fuming,
Zheng Lu,
Liu Gaojing,
Li Xiaoling,
Yun Zhiyuan,
Tang Jiebing,
Yu Yang,
Luo Shengnan,
Sun Wenji,
Feng Xiaohong,
Cheng Qian,
Tao Xue,
Wu Shuangxiu,
Tao Ji
Publication year - 2021
Publication title -
molecular oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.332
H-Index - 88
eISSN - 1878-0261
pISSN - 1574-7891
DOI - 10.1002/1878-0261.12833
Subject(s) - colorectal cancer , epigenetics , adenoma , cancer research , medicine , disease , biology , cancer , oncology , pathology , gene , genetics
Genome‐wide 5hmC profiling in cell‐free DNA acquired from CRC patients, adenoma patients, and healthy individuals revealed that the differential 5hmC‐modified regions were gathered into four clusters with no overlap, although there are a few overlapped genes shared between the different clusters. CRC patients with adenoma history showed exclusive 5hmC‐gain characteristics, which was consistent with the ‘parallel’ evolution hypothesis in adenoma.