Open AccessRETRACTED: CircRNA EPHB4 modulates stem properties and proliferation of gliomas via sponging miR‐637 and up‐regulating SOX10
Author(s) -
Jin Chen,
Zhao Jie,
Zhang ZhiPing,
Wu Ming,
Li Jian,
Liu Bo,
Bin Liao Xin,
Liao YuXiang,
Liu JingPing
Publication year - 2021
Publication title -
molecular oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.332
H-Index - 88
eISSN - 1878-0261
pISSN - 1574-7891
DOI - 10.1002/1878-0261.12830
Subject(s) - glioma , cancer research , sox10 , gene silencing , nestin , microrna , stem cell , receptor tyrosine kinase , chemistry , cancer stem cell , signal transduction , biology , microbiology and biotechnology , transcription factor , neural stem cell , biochemistry , gene
Altered expression of circEPHB4, miR‐637 or SOX10 was independently associated with overall survival of glioma patients. By sponging miR‐637, circEPHB4 up‐regulated SOX10 and its target Nestin to promote stemness and self‐proliferation of glioma cells, stimulating the malignant progression of gliomas. Consistently, silencing circEPHB4 or overexpressing miR‐637 inhibited xenograft growth of glioma cells in vivo and has therapeutic prospects.