Open AccessIdentification of RUNX1T1 as a potential epigenetic modifier in small‐cell lung cancer
Author(s) -
He Tian,
Wildey Gary,
McColl Karen,
Savadelis Alyssa,
Spainhower Kyle,
McColl Cassidy,
Kresak Adam,
Tan Aik Choon,
Yang Michael,
Abbas Ata,
Dowlati Afshin
Publication year - 2021
Publication title -
molecular oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.332
H-Index - 88
eISSN - 1878-0261
pISSN - 1574-7891
DOI - 10.1002/1878-0261.12829
Subject(s) - cancer research , gene knockdown , biology , runx1t1 , lung cancer , chromatin immunoprecipitation , gene expression , cell culture , gene , medicine , pathology , promoter , genetics
RUNX1T1 is highly expressed in ‘combined’ and ‘pure’ SCLC via genetic amplification or greater transcription, respectively. RUNX1T1 interacts with the CDKN1A (p21) promoter and is associated with reduced histone H3 acetylation, resulting in decreased p21 expression and increased E2F transcriptional activity in lung cancer cell lines. Thus, RUNX1T1 is both a potential marker and epigenetic modifier in SCLC.