Open AccessPDSS2‐Del2, a new variant of PDSS2, promotes tumor cell metastasis and angiogenesis in hepatocellular carcinoma via activating NF‐κB
Author(s) -
Zeng Tingting,
Tang Zhi,
Liang Lili,
Suo Daqin,
Li Lei,
Li Jiangchao,
Yuan Yunfei,
Guan XinYuan,
Li Yan
Publication year - 2020
Publication title -
molecular oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.332
H-Index - 88
eISSN - 1878-0261
pISSN - 1574-7891
DOI - 10.1002/1878-0261.12826
Subject(s) - metastasis , hepatocellular carcinoma , cancer research , angiogenesis , in vivo , wnt signaling pathway , epithelial–mesenchymal transition , context (archaeology) , cancer , medicine , biology , pathology , signal transduction , paleontology , biochemistry , microbiology and biotechnology
Unlike full‐length PDSS2, which has a tumor‐suppressive function, PDSS2‐Del2 promoted HCC metastasis and angiogenesis. Positive staining for PDSS2‐Del2 predicted a worse overall survival in patients with HCC. Elevated PDSS2‐Del2 expression in HCC tumor cells decreased fumarate levels and activated the canonical NF‐κB pathway. Dimethyl fumarate (DMF) might be a potential treatment for metastasis of patients with HCC.