Open AccessDeubiquitinase OTUD6A promotes proliferation of cancer cells via regulating Drp1 stability and mitochondrial fission
Author(s) -
Shi Le,
Liu Jing,
Peng Yunhua,
Zhang Jinfang,
Dai Xiangpeng,
Zhang Shuangxi,
Wang Yongyao,
Liu Jiankang,
Long Jiangang
Publication year - 2020
Publication title -
molecular oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.332
H-Index - 88
eISSN - 1878-0261
pISSN - 1574-7891
DOI - 10.1002/1878-0261.12825
Subject(s) - mitochondrial fission , carcinogenesis , microbiology and biotechnology , dnm1l , deubiquitinating enzyme , biology , mitochondrion , cancer cell , apoptosis , cell growth , cancer research , chemistry , cancer , ubiquitin , biochemistry , genetics , gene
OTUD6A deubiquitylates and stabilizes Drp1, thereby facilitating regulation of mitochondrial morphology and tumorigenesis. The depletion of OTUD6A leads to lower Drp1 levels and suppresses mitochondrial fission, and the affected cells are consequently less prone to tumorigenesis. Conversely, the overexpression of OTUD6A increases Drp1 levels and its protein half‐life and enhances cancer cell growth.