Open AccessMetabolomic profile of cancer stem cell‐derived exosomes from patients with malignant melanoma
Author(s) -
PalaciosFerrer José Luis,
GarcíaOrtega María Belén,
GallardoGómez María,
García María Ángel,
Díaz Caridad,
Boulaiz Houria,
Valdivia Javier,
Jurado José Miguel,
AlmazanFernandez Francisco M.,
AriasSantiago Salvador,
Amezcua Víctor,
Peinado Héctor,
Vicente Francisca,
Pérez del Palacio José,
Marchal Juan A.
Publication year - 2021
Publication title -
molecular oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.332
H-Index - 88
eISSN - 1878-0261
pISSN - 1574-7891
DOI - 10.1002/1878-0261.12823
Subject(s) - microvesicles , metabolomics , melanoma , cancer stem cell , metastasis , cancer research , medicine , cancer , diagnostic biomarker , biomarker , cd63 , disease , oncology , microrna , pathology , biology , bioinformatics , biochemistry , gene
Malignant melanoma (MM) is the most aggressive form of skin cancer, with increasing incidence worldwide. To date, there are no suitable clinical diagnostic, prognostic or predictive biomarkers for MM. Our data highlight the potential of metabolomic characterization of cancer stem cell‐ or serum‐derived exosomes using high‐resolution mass spectrometry for the discovery of clinically useful MM biomarkers.