Open AccessEBP2, a novel NPM‐ALK‐interacting protein in the nucleolus, contributes to the proliferation of ALCL cells by regulating tumor suppressor p53
Author(s) -
Uchihara Yuki,
Tago Kenji,
Tamura Hiroomi,
FunakoshiTago Megumi
Publication year - 2021
Publication title -
molecular oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.332
H-Index - 88
eISSN - 1878-0261
pISSN - 1574-7891
DOI - 10.1002/1878-0261.12822
Subject(s) - nucleophosmin , nucleolus , cancer research , gene knockdown , anaplastic lymphoma kinase , protein kinase b , microbiology and biotechnology , chemistry , nucleoplasm , biology , signal transduction , cytoplasm , apoptosis , biochemistry , medicine , surgery , myeloid leukemia , pleural effusion , malignant pleural effusion
Nucleophosmin‐anaplastic lymphoma kinase (NPM‐ALK) inactivates tumor suppressor p53 by negatively regulating the activation of the Akt‐mTORC1 pathway through an interaction with EBP2 in the nucleolus in anaplastic large‐cell lymphoma cells.