Open AccessTRIP13 promotes metastasis of colorectal cancer regardless of p53 and microsatellite instability status
Author(s) -
Agarwal Sumit,
Behring Michael,
Kim HyungGyoon,
Chandrashekar Darshan S.,
Chakravarthi Balabhadrapatruni V. S. K.,
Gupta Nirzari,
Bajpai Prachi,
Elkholy Amr,
Al Diffalha Sameer,
Datta Pran K.,
Heslin Martin J.,
Varambally Sooryanarayana,
Manne Upender
Publication year - 2020
Publication title -
molecular oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.332
H-Index - 88
eISSN - 1878-0261
pISSN - 1574-7891
DOI - 10.1002/1878-0261.12821
Subject(s) - cancer research , microsatellite instability , metastasis , wnt signaling pathway , colorectal cancer , gene knockdown , biology , medicine , cancer , signal transduction , cell culture , microbiology and biotechnology , gene , genetics , microsatellite , allele
This study demonstrates overexpression of TRIP13 in colorectal cancers is independent of patient's gender, age, race/ethnicity, pathologic stage (primary and liver metastatic lesions), and p53 and microsatellite instability status. Furthermore, it establishes role of TRIP13 in colorectal cancer metastasis and identifies COL6A3, TREM2, SHC3, and KLK7 as its downstream targets. Additionally, TRIP13 activates EGFR‐AKT pathway via its interaction with FGFR4.