Long noncoding RNA LINC01578 drives colon cancer metastasis through a positive feedback loop with the NF‐κB/YY1 axis | Zendy

Liu Jia | Zendy; Zhan Yang | Zendy; Wang Jiefu | Zendy; Wang Junfeng | Zendy; Guo Jiansheng | Zendy; Kong Dalu | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Long noncoding RNA LINC01578 drives colon cancer metastasis through a positive feedback loop with the NF‐κB/YY1 axis

Author(s) -

Liu Jia,

Zhan Yang,

Wang Jiefu,

Wang Junfeng,

Guo Jiansheng,

Kong Dalu

Publication year - 2020

Publication title -

molecular oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.332

H-Index - 88

eISSN - 1878-0261

pISSN - 1574-7891

DOI - 10.1002/1878-0261.12819

Subject(s) - colorectal cancer , metastasis , long non coding rna , cancer research , rna , cancer , microrna , medicine , biology , oncology , gene , genetics

LINC01578 was upregulated and correlated with metastasis and prognosis in colon cancer. Nuclear factor kappa B (NF‐κB) and Yin Yang 1 (YY1) bound to LINC01578 promoter to activate LINC01578 expression. LINC01578 interacted with and recruited EZH2 to NFKBIB promoter to repress NFKBIB expression, thereby activating NF‐κB signaling. LINC01578 upregulated YY1 via activating NF‐κB. LINC01578 enhanced colon cancer liver metastasis through forming a positive feedback loop with NF‐κB/YY1.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research