Open AccessLong noncoding RNA LINC01578 drives colon cancer metastasis through a positive feedback loop with the NF‐κB/YY1 axis
Author(s) -
Liu Jia,
Zhan Yang,
Wang Jiefu,
Wang Junfeng,
Guo Jiansheng,
Kong Dalu
Publication year - 2020
Publication title -
molecular oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.332
H-Index - 88
eISSN - 1878-0261
pISSN - 1574-7891
DOI - 10.1002/1878-0261.12819
Subject(s) - yy1 , colorectal cancer , metastasis , cancer research , downregulation and upregulation , long non coding rna , cancer , biology , transcription factor , regulation of gene expression , nf κb , promoter , signal transduction , medicine , gene expression , gene , microbiology and biotechnology , genetics
LINC01578 was upregulated and correlated with metastasis and prognosis in colon cancer. Nuclear factor kappa B (NF‐κB) and Yin Yang 1 (YY1) bound to LINC01578 promoter to activate LINC01578 expression. LINC01578 interacted with and recruited EZH2 to NFKBIB promoter to repress NFKBIB expression, thereby activating NF‐κB signaling. LINC01578 upregulated YY1 via activating NF‐κB. LINC01578 enhanced colon cancer liver metastasis through forming a positive feedback loop with NF‐κB/YY1.