Open AccessThe FABP12/PPARγ pathway promotes metastatic transformation by inducing epithelial‐to‐mesenchymal transition and lipid‐derived energy production in prostate cancer cells
Author(s) -
Liu RongZong,
Choi WonShik,
Jain Saket,
Dinakaran Deepak,
Xu Xia,
Han Woo Hyun,
Yang XiaoHong,
Glubrecht Darryl D.,
Moore Ronald B.,
Lemieux Hélène,
Godbout Roseline
Publication year - 2020
Publication title -
molecular oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.332
H-Index - 88
eISSN - 1878-0261
pISSN - 1574-7891
DOI - 10.1002/1878-0261.12818
Subject(s) - epithelial–mesenchymal transition , metastasis , cancer research , prostate cancer , lipid metabolism , peroxisome proliferator activated receptor , biology , cancer cell , fatty acid metabolism , cancer , motility , tumor progression , fatty acid , chemistry , microbiology and biotechnology , medicine , endocrinology , biochemistry , receptor
FABP12 promotes fatty acid (FA) uptake and facilitates FA trafficking to lipid droplets (storage), mitochondria (beta‐oxidation), and the nucleus (PPARγ activation). In turn, FABP12‐induced PPARγ activation regulates expression of mitochondrial FA metabolic enzymes (for energy production) and Slug (for EMT), thereby inducing metastatic transformation.