Open AccessNeurotensin receptor 1 signaling promotes pancreatic cancer progression
Author(s) -
Takahashi Kei,
Ehata Shogo,
Miyauchi Kensuke,
Morishita Yasuyuki,
Miyazawa Keiji,
Miyazono Kohei
Publication year - 2021
Publication title -
molecular oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.332
H-Index - 88
eISSN - 1878-0261
pISSN - 1574-7891
DOI - 10.1002/1878-0261.12815
Subject(s) - pancreatic cancer , cancer research , biology , cancer , tumor microenvironment , metastasis , signal transduction , microbiology and biotechnology , genetics , tumor cells
Neurotensin (NTS) receptor 1 (NTSR1) is expressed in highly malignant pancreatic cancer cells, which were established by serial orthotopic transplantations. NTS/NTSR1 signaling contributes to the progression of pancreatic cancer through the activation of MAPK and NF‐κB signaling pathways and the induction of the genes related to inflammation. Targeting NTSR1 signaling by SR48692 inhibits pancreatic cancer progression.