Open AccessGenetic factors associated with cancer racial disparity – an integrative study across twenty‐one cancer types
Author(s) -
Li Yan,
Pang Xiaodong,
Cui Zihan,
Zhou Yidong,
Mao Feng,
Lin Yan,
Zhang Xiaohui,
Shen Songjie,
Zhu Peixin,
Zhao Tingting,
Sun Qiang,
Zhang Jinfeng
Publication year - 2020
Publication title -
molecular oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.332
H-Index - 88
eISSN - 1878-0261
pISSN - 1574-7891
DOI - 10.1002/1878-0261.12799
Subject(s) - cancer , biology , single nucleotide polymorphism , computational biology , cancer prevention , gene , genetics , bioinformatics , genotype
Based on an integrative analysis using genomic data of 21 cancer types from TCGA, we identified biological factors contributing to racial disparity in cancer: XKR9 gene expression is significantly associated with overall survival for all cancers combined as well as for several individual cancers, suggesting that XKR9 could be a novel drug target for cancer immunotherapy.