Open AccessExploring the epigenetic regulation of telomerase reverse transcriptase (TERT) in human cancer cell lines
Author(s) -
McKelvey Brittany A.,
Zeiger Martha A.,
Umbricht Christopher B.
Publication year - 2020
Publication title -
molecular oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.332
H-Index - 88
eISSN - 1878-0261
pISSN - 1574-7891
DOI - 10.1002/1878-0261.12798
Subject(s) - epigenetics , telomerase , dna methylation , methylation , telomerase reverse transcriptase , biology , promoter , cancer cell , cancer , microbiology and biotechnology , cancer research , genetics , gene expression , gene
Allelic TERT promoter methylation and transcription scenarios in cancer: 1) biallelic wt; 2) monoallelic mutant; 3) monoallelic wt; 4) amplified mutant. The transcriptional start site (angled arrow) and proximal (light blue) and distal (dark blue) TERT promoter regions with allele‐specific transcription levels are depicted. Unmethylated cytosine‐guanine dinucleotide (CpG) is green; methylated CpG is red. C or T indicates a C‐>T TERT promoter mutation site. Comment on: https://doi.org/10.1002/1878‐0261.12786