Open AccessCircFNDC3B sequestrates miR‐937‐5p to derepress TIMP3 and inhibit colorectal cancer progression
Author(s) -
Zeng Wei,
Liu Yi,
Li WenTing,
Li Yi,
Zhu JinFeng
Publication year - 2020
Publication title -
molecular oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.332
H-Index - 88
eISSN - 1878-0261
pISSN - 1574-7891
DOI - 10.1002/1878-0261.12796
Subject(s) - gene knockdown , microvesicles , cancer research , angiogenesis , microrna , metastasis , biology , tumor progression , rna interference , colorectal cancer , cell growth , exon , circular rna , rna , cancer , cell culture , gene , genetics
CircFNDC3B induced TIMP3 to suppress angiogenesis to inhibit CRC cell proliferation, migration and invasion by negatively targeting miR‐937‐5p. Also, circFNDC3B exosomes could repress CRC angiogenesis by decreasing VEGFR expression.