Open AccessAdipose tissue from metabolic syndrome mice induces an aberrant miRNA signature highly relevant in prostate cancer development
Author(s) -
Massillo Cintia,
Duca Rocío Belén,
Lacunza Ezequiel,
Dalton Guillermo Nicolás,
Farré Paula Lucía,
Taha Nicolás,
Piccioni Flavia,
Scalise Georgina Daniela,
Gardner Kevin,
De Siervi Adriana
Publication year - 2020
Publication title -
molecular oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.332
H-Index - 88
eISSN - 1878-0261
pISSN - 1574-7891
DOI - 10.1002/1878-0261.12788
Subject(s) - prostate cancer , adipose tissue , microrna , metabolic syndrome , biology , cancer , cancer research , prostate , bioinformatics , medicine , pathology , endocrinology , diabetes mellitus , gene , genetics
MicroRNAs (miRNAs) released by white adipose tissue (WAT) from metabolic syndrome (MeS)‐like disease mice impact on prostate cancer (PCa) growth. We identified a signature of five miRNAs (mmu‐miR‐221‐3p, 27a‐3p, 34a‐5p, 138‐5p, and 146a‐5p) as key players implicated in the interaction between WAT and PCa in MeS mice. Besides, these miRNAs were deregulated in tumors and bloodstream of PCa patients.