Open AccessEpigenetic–smoking interaction reveals histologically heterogeneous effects of TRIM27 DNA methylation on overall survival among early‐stage NSCLC patients
Author(s) -
Ji Xinyu,
Lin Lijuan,
Shen Sipeng,
Dong Xuesi,
Chen Chao,
Li Yi,
Zhu Ying,
Huang Hui,
Chen Jiajin,
Chen Xin,
Wei Liangmin,
He Jieyu,
Duan Weiwei,
Su Li,
Jiang Yue,
Fan Juanjuan,
Guan Jinxing,
You Dongfang,
Shafer Andrea,
Bjaanæs Maria Moksnes,
Karlsson Anna,
Planck Maria,
Staaf Johan,
Helland Åslaug,
Esteller Manel,
Wei Yongyue,
Zhang Ruyang,
Chen Feng,
Christiani David C.
Publication year - 2020
Publication title -
molecular oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.332
H-Index - 88
eISSN - 1878-0261
pISSN - 1574-7891
DOI - 10.1002/1878-0261.12785
Subject(s) - dna methylation , adenocarcinoma , lung cancer , methylation , oncology , medicine , cpg site , stage (stratigraphy) , epigenetics , carcinoma , cancer , biology , gene , gene expression , genetics , paleontology
Among early‐stage non‐small‐cell lung cancer (NSCLC) patients, cg05293407 TRIM27 was significantly and exclusively associated with survival of lung squamous cell carcinoma patients, who had higher smoking intensity compared to lung adenocarcinoma patients. Generally, the significant association between cg05293407 TRIM27 and survival only remained in NSCLC patients having medium‐to‐high pack‐year of smoking. The cg05293407 TRIM27 ‐smoking synergistic interaction might account for histologically heterogeneous effects of TRIM27 DNA methylation on NSCLC survival.