Open AccessMicroenvironmental modulation of the developing tumour: an immune‐stromal dialogue
Author(s) -
Jones James O.,
Moody William M.,
Shields Jacqueline D.
Publication year - 2021
Publication title -
molecular oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.332
H-Index - 88
eISSN - 1878-0261
pISSN - 1574-7891
DOI - 10.1002/1878-0261.12773
Subject(s) - stromal cell , crosstalk , tumor microenvironment , immune system , stroma , cancer research , biology , medicine , immunology , immunohistochemistry , physics , optics
Successful establishment of a tumour relies on a cascade of interactions between cancer cells and stromal cells within an evolving microenvironment. Both immune and nonimmune cellular components have key roles in this process. Here, we review the major anti‐ and pro‐tumour factors in the early tumour microenvironment and discuss how understanding this process may be exploited in the clinic.