Open AccessPhysical activity, obesity and sedentary behavior in cancer etiology: epidemiologic evidence and biologic mechanisms
Author(s) -
Friedenreich Christine M.,
RyderBurbidge Charlotte,
McNeil Jessica
Publication year - 2021
Publication title -
molecular oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.332
H-Index - 88
eISSN - 1878-0261
pISSN - 1574-7891
DOI - 10.1002/1878-0261.12772
Subject(s) - medicine , oncology , cancer , breast cancer , prostate cancer , obesity , endometrial cancer , cancer prevention
An estimated 4 in 10 cancers are preventable through modifiable risk factors. This review summarizes the epidemiologic evidence linking physical activity, sedentary behavior, and obesity with cancer risk. We explore the possible biologic mechanisms underpinning the associations between these lifestyle factors and cancer incidence, including effects on endogenous sex steroids and metabolic hormones, insulin sensitivity, and chronic inflammation.