Open AccessDownregulation of STK4 promotes colon cancer invasion/migration through blocking β‐catenin degradation
Author(s) -
Lin ChengHan,
Hsu TaiI,
Chiou PeiYu,
Hsiao Michael,
Wang WenChing,
Chen YuChia,
Lin JenTai,
Wang JawYuan,
Lin PengChan,
Lin FornChia,
Tseng YuKai,
Cheng HuiChuan,
Chen ChiLong,
Lu PeiJung
Publication year - 2020
Publication title -
molecular oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.332
H-Index - 88
eISSN - 1878-0261
pISSN - 1574-7891
DOI - 10.1002/1878-0261.12771
Subject(s) - colorectal cancer , metastasis , cancer research , catenin , gene knockdown , hippo signaling pathway , wnt signaling pathway , cancer , downregulation and upregulation , biology , kinase , apoptosis , medicine , signal transduction , microbiology and biotechnology , biochemistry , gene
Here, we found that STK4 was significantly downregulated in colon cancer and was associated with distal metastasis and poor survival. STK4 colocalized with β‐catenin and directly phosphorylated β‐catenin resulting in its degradation via the ubiquitin‐mediated pathway. This may suggest that STK4 knockdown causes β‐catenin phosphorylation failure and subsequently β‐catenin accumulation, consequently leading to anchorage‐independent growth and metastasis in colon cancer.