Open AccessRETRACTED: The Sp1/FOXC1/HOTTIP/LATS2/YAP/β‐catenin cascade promotes malignant and metastatic progression of osteosarcoma
Author(s) -
Liu Ke,
Ni JiangDong,
Li WenZhao,
Pan BaiQi,
Yang YuTing,
Xia Qin,
Huang Jun
Publication year - 2020
Publication title -
molecular oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.332
H-Index - 88
eISSN - 1878-0261
pISSN - 1574-7891
DOI - 10.1002/1878-0261.12760
Subject(s) - cancer research , cell growth , biology , viability assay , metastasis , long non coding rna , cell culture , downregulation and upregulation , cancer , gene , biochemistry , genetics
Sp1 activated FOXC1 and they both directly transactivated HOTTIP, which recruited enhancer of zeste homolog 2 and lysine‐specific demethylase 1 to silence LATS2 and thus activated YAP/β‐catenin signaling. In summary, we showed that the Sp1/FOXC1/HOTTIP/LATS2/YAP/β‐catenin cascade presented oncogenic activities in OS cells.