RETRACTED: The Sp1/FOXC1/HOTTIP/LATS2/YAP/β‐catenin cascade promotes malignant and metastatic progression of osteosarcoma | Zendy

Liu Ke | Zendy; Ni JiangDong | Zendy; Li WenZhao | Zendy; Pan BaiQi | Zendy; Yang YuTing | Zendy; Xia Qin | Zendy; Huang Jun | Zendy

Open Access

RETRACTED: The Sp1/FOXC1/HOTTIP/LATS2/YAP/β‐catenin cascade promotes malignant and metastatic progression of osteosarcoma

Author(s) -

Liu Ke,

Ni JiangDong,

Li WenZhao,

Pan BaiQi,

Yang YuTing,

Xia Qin,

Huang Jun

Publication year - 2020

Publication title -

molecular oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.332

H-Index - 88

eISSN - 1878-0261

pISSN - 1574-7891

DOI - 10.1002/1878-0261.12760

Subject(s) - osteosarcoma , cancer research , catenin , medicine , oncology , cascade , biology , chemistry , wnt signaling pathway , gene , biochemistry , chromatography

Sp1 activated FOXC1 and they both directly transactivated HOTTIP, which recruited enhancer of zeste homolog 2 and lysine‐specific demethylase 1 to silence LATS2 and thus activated YAP/β‐catenin signaling. In summary, we showed that the Sp1/FOXC1/HOTTIP/LATS2/YAP/β‐catenin cascade presented oncogenic activities in OS cells.

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