Epidermal activation of Hedgehog signaling establishes an immunosuppressive microenvironment in basal cell carcinoma by modulating skin immunity | Zendy

GrundGröschke Sandra | Zendy; Ortner Daniela | Zendy; SzenesNagy Antal B. | Zendy; Zaborsky Nadja | Zendy; Weiss Richard | Zendy; Neureiter Daniel | Zendy; Wipplinger Martin | Zendy; Risch Angela | Zendy; Hammerl Peter | Zendy; Greil Richard | Zendy; Sibilia Maria | Zendy; Gratz Iris K. | Zendy; Stoitzner Patrizia | Zendy; Aberger Fritz | Zendy

Open Access

Epidermal activation of Hedgehog signaling establishes an immunosuppressive microenvironment in basal cell carcinoma by modulating skin immunity

Author(s) -

GrundGröschke Sandra,

Ortner Daniela,

SzenesNagy Antal B.,

Zaborsky Nadja,

Weiss Richard,

Neureiter Daniel,

Wipplinger Martin,

Risch Angela,

Hammerl Peter,

Greil Richard,

Sibilia Maria,

Gratz Iris K.,

Stoitzner Patrizia,

Aberger Fritz

Publication year - 2020

Publication title -

molecular oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.332

H-Index - 88

eISSN - 1878-0261

pISSN - 1574-7891

DOI - 10.1002/1878-0261.12758

Subject(s) - smoothened , basal cell carcinoma , biology , cancer research , skin cancer , hedgehog , hedgehog signaling pathway , immune system , immunotherapy , innate immune system , acquired immune system , immunology , microbiology and biotechnology , signal transduction , cancer , medicine , pathology , genetics , basal cell

Activation of hedgehog/glioma‐associated oncogene homolog (HH/GLI) signaling induces basal cell carcinoma (BCC) and establishes an immunosuppressive tumor microenvironment. HH/GLI signaling inhibits the activity of antitumoral T cells via programmed death ligand 1/programmed death‐1 immune checkpoint signaling and the recruitment of immunosuppressive regulatory T cells. BCCs also show strong infiltration with antitumoral neutrophils. The data support the evaluation of combination treatments with HH inhibitors and immune checkpoint blockers.

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