Open AccessGenome‐wide profiling of circulating tumor DNA depicts landscape of copy number alterations in pancreatic cancer with liver metastasis
Author(s) -
Wei Tao,
Zhang Jian,
Li Jin,
Chen Qi,
Zhi Xiao,
Tao Wei,
Ma Jingjiao,
Yang Jiaqi,
Lou Yu,
Ma Tao,
Li Xiang,
Zhang Qi,
Chen Wei,
Que Risheng,
Gao Shunliang,
Bai Xueli,
Liang Tingbo
Publication year - 2020
Publication title -
molecular oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.332
H-Index - 88
eISSN - 1878-0261
pISSN - 1574-7891
DOI - 10.1002/1878-0261.12757
Subject(s) - pancreatic cancer , metastasis , copy number variation , cell free fetal dna , chemotherapy , medicine , oncology , clinical significance , cancer research , genome , cancer , biology , gene , genetics , prenatal diagnosis , pregnancy , fetus
We used whole‐genome sequencing of cell‐free DNA (cfDNA) to obtain copy number alteration (CNA) profiles from the plasma of patients with metastatic pancreatic cancer (PC). These profiles were compared with TCGA‐derived CNA profiles of primary pancreatic tumors. CNA analysis enabled the prediction of tumor burden and tumor prognosis, and assessment of therapeutic response and clonal evolution.