Nonsense‐mediated decay factor SMG7 sensitizes cells to TNFα‐induced apoptosis via CYLD tumor suppressor and the noncoding oncogene  Pvt1 | Zendy

Yang Limeng | Zendy; Kraft Vanessa A. N. | Zendy; Pfeiffer Susanne | Zendy; MerlPham Juliane | Zendy; Bao Xuanwen | Zendy; An Yu | Zendy; Hauck Stefanie M. | Zendy; Schick Joel A. | Zendy

Open Access

Nonsense‐mediated decay factor SMG7 sensitizes cells to TNFα‐induced apoptosis via CYLD tumor suppressor and the noncoding oncogene Pvt1

Author(s) -

Yang Limeng,

Kraft Vanessa A. N.,

Pfeiffer Susanne,

MerlPham Juliane,

Bao Xuanwen,

An Yu,

Hauck Stefanie M.,

Schick Joel A.

Publication year - 2020

Publication title -

molecular oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.332

H-Index - 88

eISSN - 1878-0261

pISSN - 1574-7891

DOI - 10.1002/1878-0261.12754

Subject(s) - pvt1 , suppressor , nonsense mediated decay , cancer research , apoptosis , oncogene , tumor necrosis factor alpha , microbiology and biotechnology , biology , chemistry , long non coding rna , genetics , gene , downregulation and upregulation , rna , immunology , cell cycle , rna splicing

Yang et al . found that mutation of the nonsense‐mediated decay factor SMG7 enhanced resistance to tumor necrosis factor (TNF)‐induced apoptosis via two oncogenic pathways. Downregulation of CYLD and overexpression of the long noncoding RNA Pvt1 converge to promote NF‐κB activation. The results indicate a composite tumor suppressor role for SMG7 in response to TNF.

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