Open AccessNonsense‐mediated decay factor SMG7 sensitizes cells to TNFα‐induced apoptosis via CYLD tumor suppressor and the noncoding oncogene Pvt1
Author(s) -
Yang Limeng,
Kraft Vanessa A. N.,
Pfeiffer Susanne,
MerlPham Juliane,
Bao Xuanwen,
An Yu,
Hauck Stefanie M.,
Schick Joel A.
Publication year - 2020
Publication title -
molecular oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.332
H-Index - 88
eISSN - 1878-0261
pISSN - 1574-7891
DOI - 10.1002/1878-0261.12754
Subject(s) - downregulation and upregulation , nonsense mediated decay , suppressor , biology , oncogene , tumor necrosis factor alpha , cancer research , microbiology and biotechnology , nf κb , apoptosis , nfkb1 , tumor suppressor gene , cancer , rna , genetics , signal transduction , immunology , transcription factor , gene , carcinogenesis , cell cycle , rna splicing
Yang et al . found that mutation of the nonsense‐mediated decay factor SMG7 enhanced resistance to tumor necrosis factor (TNF)‐induced apoptosis via two oncogenic pathways. Downregulation of CYLD and overexpression of the long noncoding RNA Pvt1 converge to promote NF‐κB activation. The results indicate a composite tumor suppressor role for SMG7 in response to TNF.