Open AccessDefective postreplication repair of UV photoproducts in melanoma: a mutator phenotype
Author(s) -
Brash Douglas E.,
Seidman Michael M.
Publication year - 2020
Publication title -
molecular oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.332
H-Index - 88
eISSN - 1878-0261
pISSN - 1574-7891
DOI - 10.1002/1878-0261.12612
Subject(s) - postreplication repair , pyrimidine dimer , dna repair , thymine , phenotype , biology , chemistry , dna , genetics , dna mismatch repair , gene
In this issue, the Gabrielli laboratory and collaborators address the bulky CPD lesions created in DNA when UV joins two adjacent pyrimidines (thymine or cytosine), leading to skin cancers such as melanoma (Pavey S et al . (2019) Mol Oncol). Our understanding of postreplication repair mechanisms for bulky lesions has lagged, and the newly reported predominance of translational control in the UV response has important implications. Image taken from Creative Commons Blacklight bulb in ultraviolet by brx0, licensed under CC BY‐SA 2.0. Commentary on